USE THIS AS A LAST RESORT.
IT HAS WORKED FOR ME WITH A HERMES BUT NOT A WIZARD SO IT'S HIT AND MISS.
ANY CHANGES YOU MAKE ARE AT YOUR OWN RISK. 
One problem with windows VISTA is that it uses the new "Windows Mobile Device Centre" and not activesync which we are used to, thus our standard RUU programs will not upgrade our devices as in windows XP. This guide will show you how to configure VISTA to work just the same as XP with our RUU programs.
For this guide firstly you need to download the new drivers
xda-developers 32 bit
xda-developers 64 bit
Please note the x64 drivers are unsigned so to use them successfully you must disable driver signing.
Extract the contents to a folder on your desktop, call this folder "AS_DRIVERS". It contains the drivers from activesync which we will use instead of the native VISTA WMDC drivers when the device is in bootloader.
Now you must enter the bootloader on your device, to do this press and hold both the side ok button and the power button then put your stylus into the hole on the bottom of the device, your device will reset and show the red blue green bootloader screen. LEAVE THE DEVICE IN BOOTLOADER MODE and connect it using the USB cable to your VISTA PC.
Now navigate into the WMDC (Start>All Programs>Windows Mobile Device Center) and click on the "connection settings" menu icon
In the connection settings menu untick "allow USB connections" then press OK.
Now exit the WMDC and return to the desktop, go into the start menu and type "Services", this will take you into the local services dialogue and show a list of all services either running or registered with your pc.
Scroll down the list and make sure these services are present:
If these services are not started then double click each one and set them to Automatic start by clicking the "startup-type" drop-down menu and selecting automatic then click the start button in the same window, apply the setting by pressing OK. Now return back to the desktop again.
Go into the start menu and type "Device Manager" then run, this will take you into the device manager. Click the "+" symbol next to "Mobile Devices" and double click on "HTC USB Sync".
This will bring up the properties of the currently connected device.
Go to the "Driver" tab and click "Update Driver".
Click "Browse My Computer for Driver Software".
Select "Let me pick from a list...."
Click the "Have Disk" button.
Click "Browse" and navigate to the AS_DRIVERS folder we created earlier.
Vista x32 users select the file "wceusbsh.inf"
Vista x64 users select the file "wceusbshx64.inf"
Then click Open.
Click next and the driver will be installed (wait a moment).
Press close and escape back to the desktop now.
Now we must stop the WMDC process, start the task manager by pressing Ctrl+Shift+Escape.
Click the WMDC line and click "End Process". In the confirmation window, again press End Process.
Now re-enter the WMDC and re-enable USB connections (click connection settings and tick the box "enable USB connections").
Your RUU programs for HardSPL/Radios/WM6 ROMs should now run as desired once you are synced with WMDC. Since we have updated the driver which vista uses when the device is in bootloader mode.
THIS GUIDE WAS CREATED BY MRVANX FROM XDA DEVS